Neonatal Neocities


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JAMA Pediatrics Current Issue

Rates of Intraventricular Hemorrhage in Preterm Neonates During the First 6 Hours of Life
To the Editor We want to congratulate Nagy et al on publishing their recent article. However, we want to draw attention to several significant concerns. The authors excluded 2 studies from our 2014 meta-analysis, although these studies met their stated inclusion criteria. They also assert the inclusion of 5 studies not used in our 2014 meta-analysis; however, we acknowledge that we inadvertently omitted only 2. Notably, 1 of the studies omitted by us revealed that 10 of 25 cases (40.0%) of intraventricular hemorrhage (IVH) occurred within the first 6 hours of life (HOL). Nevertheless, the upper limit of the 95% CI for the rate of IVH within the first 6 HOL years before 2007, as indicated in the meta-analysis conducted by Nagy et al, corresponds to our estimated rate of 48%.

Rates of Intraventricular Hemorrhage in Preterm Neonates During the First 6 Hours of Life—Reply
In Reply We sincerely appreciate the opportunity to respond to the letter by Al-Abdi and Al-Aamri regarding our publication about intraventricular hemorrhage (IVH) in preterm neonates. Their recognition of the importance of ensuring the accuracy and integrity of our research is deeply appreciated. In this response, we aim to address their concerns and provide clarification regarding our methodology and findings.

Adverse Obstetric Outcomes in Fetal Congenital Heart Defects
To the Editor With great interest we read the article by Hedermann et al, which investigates adverse obstetric outcomes in pregnancies with major fetal congenital heart defects (CHDs). While the study provides valuable insights, especially in the care for women pregnant with a fetus with CHD, we have several concerns regarding the generalizability and robustness of the findings, which, in our view, would benefit from clarification.

Adverse Obstetric Outcomes in Fetal Congenital Heart Defects—Reply
In Reply We appreciate the interest from Snoep et al in our research and thank them for their comments. In their letter, they question the robustness of our findings, which we would like to clarify. Snoep et al suggest that the prevalence of major congenital heart defects (MCHDs) is lower than typically reported. However, another Danish study similarly reported the prevalence in live-born children with MCHDs to be 0.15% in 2013. Our study specifically examines adverse obstetric outcomes in pregnancies with isolated fetal MCHDs, excluding cases with genetic aberrations or extracardiac malformations, and focuses on 11 specific diagnoses. This explains the lower prevalence observed in our study population. Given this targeted approach, we believe our findings are highly relevant and generalizable to pregnancies affected by these isolated diagnoses. The data used, from the Danish Fetal Medicine Database, also include postnatally diagnosed cases, which have been missed prenatally.

Antenatal Opioid Exposure and Global and Regional Brain Volumes in Newborns
This cohort study using data from the OBOE (Outcomes of Babies with Opioid Exposure) study compares global, regional, and tissue-specific brain volumes in opioid-exposed newborns vs unexposed controls.

Neural Development, Music Therapy, and Active Noise Control in the NICU
This Viewpoint describes intrauterine and extrauterine auditory brain development and advocates for use of music therapy for preterm neonates in the neonatal intensive care unit (NICU).

Archives of Disease in Childhood current issue

Child death review processes in paediatric intensive care units: a national survey of practice against statutory and operational guidance

In 2018, Her Majesty's Government published statutory and operational guidance setting out how children’s deaths are reviewed in England, aiming to ensure practice is standardised and review of each child’s death is of uniform quality.

Objective

A national survey of paediatric intensive care units (PICUs) to review the implementation of the statutory guidance.

Design

Online survey exploring child death review (CDR) practices against expected operational standards across three domains: (1) Logistics and administration of the CDR process, (2) the CDR meeting and (3) communication with bereaved families.

Results

19/21 (91%) English PICUs, 1/1 Welsh and 1/1 Northern Irish PICUs responded to the survey request. 6/21 PICUs reported no remuneration for their CDR work. 18/21 reported routinely notifying the local child death overview panel of a child death within 48 hours as per statutory guidance. 8/21 (38%) achieved the current National Health Service England quality outcome target of holding the CDR meeting within 3 months of a child’s death. 17/21 (81%) PICUs appointed a ‘key worker’ as a single point of access to bereaved families. 12/21 (52%) PICUs routinely offered families the option to be informed of the outcome of the CDR meeting at bereavement follow-up.

Conclusions

This survey is the first to report on CDR practices in PICUs. It highlights significant variation between units in the application of national guidance. It suggests that further recommendations are required in the application of the statutory guidance to ensure greater parity between units, that learning is shared effectively between agencies and that all bereaved families receive the appropriate information and support.



Birth weight and school absences and attainment: a longitudinal linked cohort study of compulsory schooling in England
Objective

To explore how birth weight and size-for-gestation may contribute to school absences and educational attainment and whether there are different associations across sex and income groups.

Design

Longitudinal linked cohort study.

Methods

Data were drawn from the Millennium Cohort Study, a nationally representative cohort of children born in 2000–2001; percentage of authorised and unauthorised absences from Year 1 to Year 11, and Key Stage test scores at ages 7, 11 and 16 in English and Maths were linked from the National Pupil Database. Birth outcomes and covariates were derived from the 9-month survey, and linear regressions with complex survey weights were fitted.

Results

Being born small-for-gestational-age (vs average-for-gestational-age) was associated with an increase of 0.47%, 0.55% and 0.40% in authorised absences in Years 1, 3 and 4 (n=6659) and with a reduction of 0.16–0.26 SD in all English and Maths test scores (n=6204). Similar associations were found for birth weight. After adjusting for prior test scores, English (b=0.07) and Maths (b=0.05) performance at age 11 remained associated with birth weight. Socioeconomic status modified the associations: there were larger disparities in test scores among higher-income families, suggesting that higher income did not compensate for being born small-for-gestational-age.

Conclusion

Children born smaller missed slightly more classes (~1 day per year) during primary school and had lower English and Maths performance across compulsory education. Exploring specific health conditions and understanding how education and health systems can work together to support children may help to reduce the burden.



Pediatric Research

Family reflections: congenital diaphragmatic hernia

Pediatric Research, Published online: 14 June 2025; doi:10.1038/s41390-025-04184-w

Family reflections: congenital diaphragmatic hernia

Pulmonary perfusion with dynamic PEEP recruitment or sustained inflation at birth in preterm lambs

Pediatric Research, Published online: 13 June 2025; doi:10.1038/s41390-025-04183-x

Pulmonary perfusion with dynamic PEEP recruitment or sustained inflation at birth in preterm lambs

Prevention of unplanned extubation in neonates with silk tie securement

Pediatric Research, Published online: 12 June 2025; doi:10.1038/s41390-025-04168-w

Prevention of unplanned extubation in neonates with silk tie securement

Early prediction of bronchopulmonary dysplasia: comparison of modelling methods, development and validation studies

Pediatric Research, Published online: 12 June 2025; doi:10.1038/s41390-025-04170-2

Early prediction of bronchopulmonary dysplasia: comparison of modelling methods, development and validation studies

Journal of Perinatology

Effects of a remote patient monitoring program on cost of care for neonates with inadequate oral feeding

Journal of Perinatology, Published online: 12 June 2025; doi:10.1038/s41372-025-02334-w

Effects of a remote patient monitoring program on cost of care for neonates with inadequate oral feeding

Associations between antibiotic exposure intensity, intestinal microbiome perturbations, and outcomes in premature neonates with bacteremia

Journal of Perinatology, Published online: 09 June 2025; doi:10.1038/s41372-025-02330-0

Associations between antibiotic exposure intensity, intestinal microbiome perturbations, and outcomes in premature neonates with bacteremia

Introduction of human milk fortifier and the development of neonatal acute kidney injury

Journal of Perinatology, Published online: 07 June 2025; doi:10.1038/s41372-025-02326-w

Introduction of human milk fortifier and the development of neonatal acute kidney injury

Factors associated with rates and durations of cord clamping practice compliance in preterm neonates of <33 weeks’ gestation

Journal of Perinatology, Published online: 06 June 2025; doi:10.1038/s41372-025-02328-8

Factors associated with rates and durations of cord clamping practice compliance in preterm neonates of <33 weeks’ gestation

Factorial vignettes describe suspected early onset sepsis practice variation in a multicenter NICU antibiotic stewardship collaborative

Journal of Perinatology, Published online: 03 June 2025; doi:10.1038/s41372-025-02325-x

Factorial vignettes describe suspected early onset sepsis practice variation in a multicenter NICU antibiotic stewardship collaborative

Targeting discrepancies in linear growth measurements in the neonatal intensive care unit through nursing interventions: a quality improvement initiative

Journal of Perinatology, Published online: 02 June 2025; doi:10.1038/s41372-025-02327-9

Targeting discrepancies in linear growth measurements in the neonatal intensive care unit through nursing interventions: a quality improvement initiative